TP53 loss initiates chromosomal instability in fallopian tube epithelial cells
High-grade serous ovarian cancer (HGSOC) Bowls Glass originates in the fallopian tube epithelium and is characterized by ubiquitous TP53 mutation and extensive chromosomal instability (CIN).However, direct causes of CIN, such as mutations in DNA replication and mitosis genes, are rare in HGSOC.We therefore asked whether oncogenic mutations that are